LATISSE® makes lash growth possible because of its active ingredient: bimatoprost. Although the precise mechanism of action is not known, research suggests that the growth of eyelashes occurs by increasing the percent of hairs in, and the duration of, the anagen (or growth) phase. Lashes can grow longer, thicker and darker because bimatoprost can also prolong this growth phase.
In patients using ophthalmic prostaglandins such as travoprost and latanoprost, as well as prostamides like bimatoprost, it has been anecdotally noted that there had been an increase in diameter, density and length of eyelashes. Allergan has initiatedclinical trials investigating the usage of Lumigan as a cosmetic drug. On December 5, 2008, the FDA Dermatologic and Ophthalmic Drugs Advisory Committee voted to approve bimatoprost for the cosmetic use of darkening and lengthening eyelashes. The medical term for this is treatment of hypotrichosis, however, the FDA approval is for purely cosmetic purposes.
According to Allergan's package labeling, users of its Latisse cosmetic product didn't develop darker irises in clinical studies; however, "patients should be advised about the potential for increased brown iris pigmentation which is likely to be permanent."
Several cosmetics companies have released products based on prostaglandin analogs, as non-drug cosmetics.
- Age Intervention Eyelash by Jan Marini Skin Research
- RevitaLash by Athena Cosmetics Corp.
- MD Lash Factor by PhotoMedex Inc.
These companies have been sued by Allergan for patent infringement.The FDA has seized Age Intervention Eyelash as an "unapproved and misbranded drug" because Jan Marini Skin Research promoted it as something that increases eyelash growthand because it is "adulterated" with bimatoprost.
Reductions in orbital fat (i.e., fat around the eye) have been observed in patients using bimatoprost as glaucoma therapy. Of particular interest, the loss of orbital fat was unilateral in patients who used bimatoprost on only one eye.The effect appears reversible upon cessation of bimatoprost use. The effect is likely to explain deepening of the lid sulcus described in a series of three patients on bimatoprost. The mechanism for the apparent fat reduction remains unclear. However, bimatoprost is chemically analogous to prostaglandin F2 alpha (PGF2alpha), a compound which is known to reduce fat by inhibition of adipocyte differentiation and survival.
Possible side effects of this medication are:
- May cause blurred vision.
- May cause eyelid redness.
- May permanently darken eyelashes.
- May cause eye discomfort.
- May eventually cause permanent darkening of the iris to brown.
- May cause a temporary burning sensation during use.
- May cause thickening of the eyelashes.
- It may cause unexpected growth of hair if applied inappropriately, on the cheek, for example.
- It may cause infection if the one-time applicators which come with the genuine product are reused.
- Lashes may grow so long that they become ingrown and scratch the cornea.
- May cause darkening of the eyelid or of the area beneath the eye.
What is LATISSE® (bimatoprost ophthalmic solution) 0.03%?
LATISSE® solution is a prescription treatment for hypotrichosis used to grow eyelashes, making them longer, thicker and darker.
What is hypotrichosis of the eyelashes?
Hypotrichosis is another name for having inadequate or not enough eyelashes.
How does LATISSE® work?
LATISSE® is believed to affect the growth (anagen) phase of the eyelash hair cycle in two ways: first, it increases the length of this phase; and second, it increases the number of hairs in this growth phase. The exact way it works is unknown.
How do I apply LATISSE®?
LATISSE® solution is a once-a-day treatment you apply yourself each evening to the base of the upper eyelashes. See the full instructions in How to Apply, and apply as instructed by your doctor.
You should always only use the FDA-approved sterile applicators to apply LATISSE® directly to the base of your upper eyelashes. The applicators have been specially designed and manufactured to meet FDA standards.
How soon will I see results?
LATISSE® users may see results starting at 8 weeks with full results at 12 to 16 weeks. The growth is gradual overnight, over time.
Is LATISSE® a replacement for mascara?
No, LATISSE® does not work in place of mascara. LATISSE® is a solution treatment for inadequate or not enough lashes and requires a prescription from a doctor. However, mascara can be used on your eyelashes in addition to LATISSE®.
Is LATISSE® (bimatoprost ophthalmic solution) 0.03% different from nonprescription products that indicate eyelash growth?
LATISSE® solution is the first and only prescription treatment approved by the FDA for inadequate or not having enough eyelashes, growing them longer, fuller and darker.
What if I forget to apply one night? Or a few nights?
If you miss an application or a few, don't try to catch up. Just apply the LATISSE® treatment the next evening and stay on schedule.
What happens if I stop using LATISSE®?
If you stop using LATISSE®, your eyelashes are expected to return to their previous appearance over several weeks to months.
Can I get a prescription for LATISSE® from any doctor?
First, ask your doctor if LATISSE® is right for you. Although any doctor can prescribe LATISSE®, some may be more familiar with this product than others. That's why we encourage you to use the interactive "Find-a-Doctor" locator tool to find a doctor near you who will more likely know about this FDA-approved treatment. When making an appointment, be sure to tell the receptionist that you want to find out more about LATISSE®.
What are the possible side effects of LATISSE®?
The most common side effects after using LATISSE® solution are an itching sensation in the eyes and/or eye redness. This was reported in approximately 4% of patients. LATISSE® solution may cause other less common side effects which typically occur on the skin close to where LATISSE® is applied, or in the eyes. These include skin darkening, eye irritation, dryness of the eyes, and redness of the eyelids.
What should I do if I get LATISSE® in my eye?
LATISSE® solution is an ophthalmic drug product. If any gets into the eye, it is not expected to cause harm. The eye should not be rinsed.
Who should NOT use LATISSE®?
Do not use LATISSE® solution if you are allergic to one of its ingredients.
What are the ingredients in LATISSE®?
Active ingredient: bimatoprostInactive ingredients: benzalkonium chloride; sodium chloride; sodium phosphate, dibasic; citric acid; and purified water. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. The pH during its shelf life ranges from 6.8 — 7.8.
What is skin hyperpigmentation?
This is a common, usually harmless condition in which areas of skin become darker than the surrounding skin color. This occurs when there is an increase in the melanin, the brown pigment that produces normal skin color, in the skin. Skin hyperpigmentation is a possible side effect of LATISSE®, but may be reversible after discontinuation of the product.
What is elevated intraocular pressure (IOP)?
This is a condition where the pressure inside the eye is higher than normal. LATISSE® may decrease IOP. So talk to your doctor if you are using IOP-lowering medications. Concurrent administration of LATISSE® and certain IOP-lowering medications in ocular hypertensive patients should be closely monitored for changes in intraocular pressure.
What should I do if I experience eye redness?
Eye redness may occur immediately after use, but should usually last only for a short period of time. Eye redness alone is not an allergic reaction or inflammation, and doesn't mean that your eyes are being harmed. Please use the LATISSE® applicators as instructed to help to minimize the occurrence of eye redness.
Could LATISSE® cause the color of my eyes to change?
Increased brown iris pigmentation has occurred when similar medications were instilled directly into the eye to treat elevated intraocular pressure/glaucoma. Although iris pigmentation was not reported in clinical studies with LATISSE®, patients should be advised about the potential for increased brown iris pigmentation which is likely to be permanent.
What should I use to apply LATISSE®?
You should always only use the FDA-approved sterile applicators to apply LATISSE® solution directly to the base of your upper eyelashes. The applicators have been specially designed and manufactured to meet FDA standards, and ensure that the correct dose of LATISSE® is applied.
Why do the directions say to only apply LATISSE® solution to the base of the upper eyelashes?
A clinical trial of LATISSE® was conducted on patients who applied the product to the base of their upper lashes only. Applied nightly, the transfer of LATISSE® solution from the upper to lower eyelid may occur naturally because the eyelids are closed and the eyelashes touch each other. Over application may increase the chance of experiencing side effects. To ensure safety and maximize effectiveness, please follow the directions provided.
What should I do if I experience eye itching?
Eye itching may occur immediately after use, but should usually last only for a short period of time (one to two weeks during initial use). Eye itching alone is not an allergic reaction, and doesn’t mean that your eyes are being harmed. Consult your doctor if the itching persists or you notice other symptoms as well.
- Anophthalmia is a medical term used to describe the absence of the globe and ocular tissue from the orbit.
- This was first reported more than 400 years ago, yet it is only recently that significant reconstructive options became available.
- There are many reasons why one might lose an eye.
- Surgeries which result in anophthalmos
- What is Blepharoplasty?
- Your eyes including your eyelids, are perhaps one of the first things people notice in you. This makes your eyes and eyelids one of the most important components for an appealing facial expression and aesthetic appearance. Any visible change in the shape or size of the orbital or periorbital region can spoil the look of your face.
- As you age and grow older, your eyelids may become ‘droopy’ or ‘baggy’ due to the stretching of your eyelid skin and gradually decreasing tone of your eyelid muscles. Your droopy eyelids and brow together cut a sorry figure for your face making you look tired, sleepy and haggard, further leading to eyelid or brow straining or both. In extreme cases, your saggy, baggy eyelids can even obstruct your vision, particularly peripheral vision causing difficulty in reading or driving.
- Blepharoplasty ensures cosmetic or functional corrections to the area around your eyes to enhance your look or to correct any abnormalities in function.
- Blepharospasm is defined as an abnormal, involuntary, sustained and forceful closure or twitching of the eyelids. It is derived from the Greek word ‘blepharon’ which means eyelid, and ‘spasm’ which is an uncontrolled muscle contraction. Blepharospasm is usually associated with headache, eyebrow strain and occasionally loss of vision.
- Isolated blepharospasm is rare and represents a minority of patients presenting with blepharospasm. Blepharospasm is commonly associated with lower facial spasms as part of a syndrome or disease complex. Some examples are:
- Meige Syndrome: Characterized by spasm of the eyelids and midface.
- Brueghel’s Syndrome: Presents with blepharospasm and marked spasms in the lower face and neck.
- Segmental Cranial Dystonia: In addition to the usual spasms of the eyelids and facial muscles it is associated with spasms along distribution of various cranial nerves, most frequently involving the Facial Nerve.
- Generalized Dystonia: Presents with spasms across various body parts in addition to blepharospasm and facial spasms.
- Brow Lift
- A forehead lift, also known as a browlift or browplasty, is a cosmetic surgery procedure used to elevate a drooping eyebrow that may obstruct vision and/or to remove the deep worry lines that run across the forehead and may portray to others anger, sternness, hostility, fatigue or other unintended emotions
- Congenital anomolies include :
- Eyelid Disorders
- Orbital Disorders
- Congenital Ptosis
- Congenital Nasolacrimal Duct Obstruction
- Dry Eye
- What is Dry Eye?
- Dry eye is a reduction in your eye’s ability to produce sufficient natural tears.
- Insufficient tear production can lead to irritation and pain, and even scarring of the cornea (the transparent part of the eye that covers the pupil and iris).
- Many people will experience dry eye symptoms at some point in their lives.
- Often due to environmental factors such as indoor heating or air conditioning, it can also be caused by occupational factors such as prolonged computer use.
- Dry eye symptoms can affect anyone.
- Some of the symptoms of dry eye include a burning sensation or gritty feeling in the eyes. You may also experience decreased tolerance to contact lens wear or sensitivity to light.
- Eyelid Laxity
- Eyelids protect your eyes from any foreign bodies while keeping them lubricated throughout. Any alteration in the shape, position or function of your eyelids can predispose your eyes to a plethora of ailments or interfere with our vision.
Our eyelid is a complex structure consisting of three theoretical layers:
- Anterior Layer contains the skin and orbicularis muscle
- Middle Layer contains the orbital septum and eyelid retractors
- Posterior Layer contains tarsus and conjunctiva.
- Eyelid malpositions include any unnatural or incorrect positioning and orientation of eyelids due to various factors that influence any of the three layers of the eyelids. They may be caused due to ageing, trauma, scarring, birth defects or medical disease involving any or all of the three layers.
- The most common forms of eyelid malposition are eyelid retraction, ptosis, entropion and ectropion.
- The world of cosmetic surgery has advanced tremendously over the last two decades. New procedures have emerged that can make an individual look and feel younger in a matter of a few minutes. Amongst the vast number of cosmetic procedures currently available, the face lift is a commonly performed one that is sought after by both men and women. Here we shall take a look at this procedure in a little more detail.
- What is a face lift? - A face lift is called a rhytidectomy in the world of medicine. It involves tightening the muscles of the face and smoothening of the skin so that the face appears younger. - However, it must be remembered that a face-lift is not an anti ageing solution.
- Lacrimal System
- - The lacrimal gland produces tears which enter into the "duct"
that drain the tears from the eye into the nose. The most common symptoms are If one has a plugged up "tear duct," not only will tears spill over the eyelids and
run down the face, but the stagnant tears within the system can become infected.
(1) excess tearing (tears may run down the face) and
(2) mucous discharge
- This may lead to recurrent red eyes and infections.
- The excessive tearing can also produce secondary skin changes on the lower eyelids.
- Patients with lagophthalmos have an inability to close eyelids. This may occur, for instance, in patients with Thyroid eye disease.
- LATISSE® makes lash growth possible because of its active ingredient: bimatoprost. Although the precise mechanism of action is not known, research suggests that the growth of eyelashes occurs by increasing the percent of hairs in, and the duration of, the anagen (or growth) phase. Lashes can grow longer, thicker and darker because bimatoprost can also prolong this growth phase.
- Orbital Tumors
- - Orbital Tumor is any tumor that occurs within the orbit of the eye. The orbit is a bony housing in the skull about 2 inches deep that provides protection to the entire eyeball except the front surface. It is lined by the orbital bones and contains the eyeball, its muscles, blood supply, nerve supply, and fat.
- Tumors may develop in any of the tissues surrounding the eyeball and may also invade the orbit from the sinuses, brain, or nasal cavity, or it may metastasize (spread) from other areas of the body. Orbital tumors can affect adults and children. Fortunately, most are benign.
- - Ptosis is an abnormally low position (drooping) of the upper eyelid
- Ptosis occurs when the muscles that raise the eyelid (levator and Müller's muscles) are not strong enough to do so properly.
- It can affect one eye or both eyes and is more common in the elderly, as muscles in the eyelids may begin to deteriorate.
- Compare with dermatochalsis (extra skin and fat)
- Skin Rejuvination
- A radiant, smooth, youthful skin is the essence of beauty and trendy looks. Skin care routine highly contributes in the slowing down of rate of aging of the skin. Choosing the right skin care products for your skin type enhances your beauty keeping the skin cleansed, moisturized and well toned. Use of superficial skin resurfacing treatments to counter fine lines and wrinkles, acne scars and blemishes before they deepen ensures skin rejuvenation.
- Skin Tumors
- Cancer of the eyelid, like any other cancer, can be a worrying thing. Treatments are variable and depend on the type of cancer. In this article, we shall take a brief look at the different kinds of eyelid tumors.
- A symblepharon is a fibrous tract that connects bulbar conjunctiva to conjunctiva on the eyelid.
- Graves' disease is an autoimmune disease.
It most commonly affects the thyroid, causing it to grow to twice its size or more (goiter), be overactive, with related hyperthyroid symptoms such as increased heartbeat, muscle weakness, disturbed sleep, and irritability. It can also affect the eyes, causing bulging eyes (exophthalmos).
- Eye injuries are extremely common with over 2 million cases reported every year that require medical treatment. Blindness in one eye is most commonly due to cataract and this is followed closely by eye injuries. In addition, in children, injury to the eye is a recognized as the most common cause of blindness in one eye that is not due to a birth defect.